Mucoadhesive buccal patches formulations reported in the literature. Buccal methyltestosterone brand namemetandren, ciba. Formulation and evaluation of buccal patches of diclofenac. In principle, mucoadhesive buccal patch are novel and promising drug delivery systems with different forms including matrix or reservoir monomultilayered designs. Tizanidine hydrochloride thcl is a centrally acting. Preparation of buccal mucoadhesive controlled drug delivery systems of lercanidipine hydrochloride using various mucoadhesive and rate controlling polymers either alone or in combination. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Oct 14, 2012 buccal drug delivery and mucoadhesivitymucoadhesion of the device is a key elementthe term mucoadhesive is commonly used for materials that bind to the mucin layer of a biological membraneachieve systemic delivery of drugs include tablets, patches, tapes, films, semisolids and powders. Patches with any imperfections, entrapped air, or differing in thickness, weight or content uniformity were excluded from further studies. Development of mucoadhesive patches for buccal administration of prochlorperazine. Various studies have been conducted on buccal delivery of drugs using mucoadhesive polymers. Preparation of patches the buccal patches were prepared using the solvent casting method. Pdf development of mucoadhesive patches for buccal.
They adhere to buccal mucosa for extended period of time. The new drug delivery systems that have been developed and developing are the mucoadhesive drug delivery systems, drug patches, transdermal patches etc. Mucoadhesive drug delivery system linkedin slideshare. The backing membrane was prepared by using sodium alginate. Because of the properties such as hydrophobicity, low water permeability, drug impermeability, and moderate flexibility, ethyl cellulose was used as a backing layer polymer 8. Jun 06, 20 bilayer nct mucoadhesive patches were prepared and evaluated by obaidat et al. Buccal mucoadhesive tablets 12 buccal mucoadhesive patches gels buccal mucoadhesive tablets of lercanidipine. Mucoadhesive polymers these are the main component for adhesion.
The dissolution test was performed using 500 ml of phosphate buffer ph 6. The major categories are wetting theory, adsorption theory, diffusion theory, electrostaticic theory, and fracture theory. The surface ph of all the patches c1c7 was near 6 aframian et al. Mucoadhesive buccal patches containing propranolol hydrochloride were prepared using the solvent casting method. However, buccal patch offer greater flexibility and comfort than the other devices. Formulation and evaluation of buccal patches of diclofenac sodium. Casein, the major milk protein, comprises about 80 % total protein. Preparation of mucoadhesive buccal patches buccoadhesive patches containing varying amounts of chitosan and pectin were prepared by solvent casting method as reported by kaur et al. Formulation, development and invitro evaluation of mucoadhesive.
Buccal patches films they are long, flat, thin thickness, transparent with high surface area. Jagadeesh singh the mucoadhesive drug delivery system is a popular novel drug delivery method because mucous membranes are relatively permeable, allowing for the rapid uptake of a drug into the systemic circulation and avoiding the first pass metabolism. A clinical perspective on mucoadhesive buccal drug delivery. A clinical perspective on mucoadhesive buccal drug. Formulation and evaluation of buccal patches of simvastatin by using different polymers shalini mishra1, g. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. The use of mucoadhesive polymers in buccal drug delivery has a greater application. The major categories are wetting theory, adsorption theory, diffusion theory, electrostatic theory, and fracture theory. Comparison of the systemic and local pharmacokinetics, safety and. Due to the versatility of the manufacturing processes, the release can be oriented either towards. Buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to. Ppt buccal drug delivery system powerpoint presentation. Buccal mucoadhesive tablets are dry dosage forms that have to be moistened prior to placing in contact with buccal mucosa. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture.
This paper also adds a note on the buccal mucoadhesive dosage forms like buccal films, buccal tablets, buccal gels and ointments, and buccal patches. Buccal mucoadhesive tablets are dry placing in contact with buccal mucosa. The backing layer of buccal patch was attached to the glass slide with. The quan tity of different polymers was optimized as per details in table i.
For each formulation, three randomly selected patches with surface area 1 cm 2 were used. Impermeable backing is applied to control the direction of drug delivery to reduce patch. Glimepiride shows the high in conventional tablet dosage form, which can be terminated by buccal dosage form. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and. Adhesion of a matter to this layer is hence called mucoadhesion. Cydot is an example of a patch technology where the patch adheres to the buccal mucosa for a period of up to 24 hours to slowly release melatonin for normalizing circadian rhythms. Development of mucoadhesive patches for buccal administration. Avoids firstpass hepatic metabolism prochlorperazine brand name oreton,schering buccastem, alternative to enteral tablet department of pharmaceutical technology,41020 lj institute of pharmacy, ahmedabad 52. Mucoadhesive bilayered patches for administration of. Mdds utilizes the property of bioahesion of certain watersoluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time. The mucoadhesive buccal film of lisinopril were prepared by using various polymers like hpmc k4m, sodium cmc, pvp k30, eudragit rl 100, carbopol 934 by solvent casting method and evaluated for physical appearance, thickness, weight uniformity, folding endurance,percentage swelling index, percentage moisture content, drug diffusion studies and drug content estimation.
Formulation and evaluation of mucoadhesive buccal patches. Sathish and shayeda abstract patches of cyproheptadine hydrochloride cph which is a sedating antihistamine with antimuscarinic, serotoninantagonist, and calciumchannel blocking action. In vitro release was carried out in simulated saliva solution using modified usp type ii apparatus at 50 rpm. The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. Buccal patches buccal patch is a nondissolving thin matrix modifiedrelease dosage form composed of one or more polymer films or layers containing the drug andor other excipients.
Many mucoadhesive buccal films have been formulated to release drugs locally in order to treat for fungal infections in the oral cavity, such as oral candidiasis donnelly et al. Introduction ecent years have seen an increasing interest in the development of novel mucoadhesive buccal dosage forms. India,2institute pharmacy,bhagwant ajmerraj india, 3defence research laboratory, tejpur, assam india email. Design of a buccal mucoadhesive, nanoparticles based. The reported mucoadhesive buccal patches drug delivery system are summarized here. The thickness of patches was assessed using a micrometer screw gage mitutoyo, japan. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. The in vitro release rate of timolol maleate from buccal mucoadhesive patches was determined using usp dissolution testing apparatus ii paddle type. Though there is ample of work done in this field of mucoadhesive patch development but clinical usage is flimsy. Pdf evaluation of a mucoadhesive buccal patch for delivery.
The buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesiveimpermeable backing is applied to control the direction of drugdelivery. Buccal film may be preferred over adhesive tablet in terms of flexibility and comfort. Arx proved expedient and bilayer buccal films as a drug delivery system ascertained. For development of mucoadhesive, bilayered buccal patches of sumatriptan succinate, chitosan was used as base matrix polymer 7,8. These are useful for the systemic delivery of drug as well as for local targeting of drug to a particular region of the body. The drug containing layer was prepared by using pectin.
Development of tizanidine hclmeloxicam loaded mucoadhesive. Development of controlled release mucoadhesive buccal. Buccal patchesfilms they are long, flat, thin thickness, transparent. Three different polymers were used hpmc k4m, hpmc k15m and scmc, along with plastisizer peg 400 and a hydrophilic polymer pvp k30, so that the patch could be made pliable.
The results of the study demonstrated that xanthan mucoadhesive buccal patches are potential candidates for controlled biphasic nicotine delivery. Mucoadhesive buccal patches of salbutamol sulfate salbutamolb2. Preparation of buccal mucoadhesive controlled drug delivery systems of lercanidipine hydrochloride using various mucoadhesive and. Formulations of buccal dosage forms include adhesive tablets3, 4, gels5, 6 and patches7, 8, of which patches are preferable in terms of flexibility and comfort 9. An approach to prepare buccal patches using chitosan and hpmc polymers jose, jobin, charyulu, r. Index terms fluxotine hcl, buccal patches, invitro release, evaluation i. Comparison of the systemic and local pharmacokinetics, safety and tolerability of clonidine mucoadhesive buccal tablets with reference clonidine oral tablets in. The results indicate that suitable bioadhesive buccal patches with desired permeability could be prepared. The novel type buccal dosage forms include buccal adhesive tablets, patches, films, semisolids ointments and gels and powders. Mucoadhesive drug delivery system ppt linkedin slideshare. Research paper formulation and evaluation of pimozide. Mucoadhesive buccal patches based on interpolymer complexes of. The fresh buccal mucosa is tied on the glass slide, and a mucoadhesive patch is wetted with 1 drop of phosphate buffer ph 6. The study was aimed at developing mucoadhesive buccal tablet containing carvedilol.
Chitosan based mucoadhesive buccal patches containing. The mucoadhesive buccal drug delivery system offers several advantages as compared to traditional methods of systemic drug administration 2, 3. The mucoadhesive buccal patches for systemic administration of salbutamol sulphate in the oral cavity has been developed using eudragit s100 as film forming polymer and hpmc k 15 as mucoadhesive. Formulation and evaluation of buccal patches of diclofenac sodium shubhra pandey abstract. Formulation and characterization of mucoadhesive buccal films. Formulation and evaluation of mucoadhesive buccal patches of. Overview and future potential of buccal mucoadhesive films. The formulations were tested for in vitro drug permeation studies, buccal absorption, in vitro drug release studies, moisture absorption as well as for in vitro and in vivo bioadhesion. A more specific term than bioadhesion is mucoadhesion.
Development of controlled release mucoadhesive buccal patches. The glass slide is then put in the beaker, which is filled with 200 ml of the phosphate buffer ph 6. New insight into the fabrication of smart mucoadhesive. Reserviour type the buccal patch designed in a reservoir system contains a cavity for the drug and additives separate from the adhesive. The patch may contain a mucoadhesive polymer layer which bonds to the oral mucosa, gingiva, or. Formulation and evaluation of pimozide buccal mucoadhesive patches 741 evaluation of the patches formulated patches were subjected to the preliminary evaluation tests. The use of mucoadhesive polymers in buccal drug delivery has a greater. The surface ph was measured by means of ph paper placed on the surface of the swollen patch. Formulation and evaluation of mucoadhesive buccal patch of. Pdf buccal tablet as a promising mucoadhesive drug delivery. Development of mucoadhesive patches for buccal administration of ibuprofen article in journal of controlled release 991.
Aug 06, 2012 formulation and evaluation of mucoadhesive buccal patches of labetalol. Different polymeric systems can be used for the development of buccal mucoadhesive patches. Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process. Bidirectional patches release drug in both the mucosa and the mouth drug mucoadhesive matrix. The study was designed to develop bioadhesive patches of carvedilol hydrochloride using chitosan ch and pectin pe interpolymer. Adhesive polymer itself act as drug carrier or adhesive layer link between drug loaded layer and mucosa. They can be prepared by two methods solvent casting method direct milling method 32020 31 department of pharmaceutical technology, lj institute of pharmacy, ahmedabad. Patel nagar, dehradun, uttarakhand248001, india the objective of this study was to develop mucoadhesive buccal tablets of simvastatin using mucoadhesive polymers. Novel drug delivery systems ndds are the system where the man searches for new methods of entry of drugs in to the body in order to show its activity in the body. Formulation and evaluation of mucoadhesive buccal film of. Chitosan was used as bioadhesive polymer and different ratios of chitosan to pvp k. Formulation, development and invitro evaluation of. The buccal mucosa is an attractive route for systemic delivery of many drugs since it is relatively permeable with a rich blood supply.
The prepared mucoadhesive buccal patches were evaluated for swelling index, residence time, folding endurance, tensile strength and mucoadhesive strength. Evaluation of in vitro release and mechanical properties chandra sekhar kollia, ramesh gannub, vamshi vishnu yamsanib, kishan vb and madhsudan rao yamsanib acollege of pharmacy and health sciences, mercer university, atlanta, georgia, usa30341. Formulation and evaluation of mucoadhesive buccal patch. Formulation and evaluation of a bioadhesive patch for. Each patch was weighed individually on an analytical balance shimadzu, japan and the average weights calculated 18 2. Specific processes include mechanical interlocking, electrostatic, diffusion interpenetration, adsorption. Formulation and evaluation of buccal patches for delivery. Most mucosal surfaces such as in the gut or nose are covered by a layer of mucus.
Preparation of mucoadhesive patches for buccal administration. The recent innovations and applications are well explained in this paper. Attempts have been made to formulate various mucoadhesive devices including tablets 11, films 12, patches,14, disks 15,16, strips 17, ointments 18 and gels 19. Formulation and evaluation of buccal patches for delivery of atenolol. Mucoadhesive agents are usually polymers containing hydrogen bonding groups that can be used in wet formulations or in dry powders for drug. Mucoadhesive drug delivery system is a part of controlled delivery system. Mucoadhesive buccal patches based on interpolymer complexes. Buccal mucoadhesive tablets 12 buccal mucoadhesive patchesgels buccal mucoadhesive tablets of lercanidipine. Research paper formulation and evaluation of pimozide buccal. Data sources include ibm watson micromedex updated 4 may 2020, cerner multum updated 4 may 2020, wolters kluwer updated. Shamim qureshi2, jitendra patel3, uttam prasad panigrahi3, i. Formulation and evaluation of a bioadhesive patch for buccal. Buccal patches were left to swell for 1 hour on the surface of 2% agar plate, it was allowed to stand until it is solidified to form a gel at room temperature. Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin.
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